Jan 2023 Update: BioGX in silico analysis of SARS-CoV-2 Variants of Concern
BioGX continuously monitors the evolution of COVID-19 variants to ensure our market leading SARS-CoV-2 RT-PCR tests will continue to detect emerging variants without impacting performance.
BioGX has completed in-silico analysis of over 930,000 SARS-CoV-2 genome sequences available as of December, 2022. Sequence analysis compared the available Omicron genomes against the SARS-CoV-2 nucleocapsid (N-gene), membrane (M-gene), and RdRp coding region of the ORF1a gene (RdRp) targeted by BioGX products. In-silico analysis and empirical testing of the Omicron variants confirmed gene mutations present as of this analysis, will not affect the performance of the BioGX portfolio of SARS-CoV-2 products.
BioGX portfolio of SARS-CoV-2 products
- BioGX Xfree™ COVID-19 Direct RT-PCR – FDA EUA
- BioGX SARS-CoV-2 HMP – N1, N2 & RNase P Multiplex
- BioGX COVID-19, Flu A, Flu B, RSV RT-PCR for BD MAX™
- BioGX SARS-CoV-2 N1, Flu A, Flu B, RSV A/B (RUO)
U.S. CDC and WHO Variants of Concern Omicron Lineages* |
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WHO designation | Pango lineage | GISAID clade |
Nextstrain clade | Emergence Location (Date) | No. Sequences Analyzed
(DEC 2022) |
% Clades Detected for
N1 Target |
||
Omicron | B.1.1.529 | GR/484A | 21K, 21L, 21M, 22A, 22B, 22C, 22D | Multiple Countries (NOV 2021) | 61,891 | > 99% | ||
Omicron Sublineages Analyzed by BioGX |
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Omicron sublineage | Nextstrain clade | Emergence Location (Date) | No. Sequences Analyzed
(DEC 2022) |
|||||
BA.1* | 21K | Southern Africa (NOV 2021) | 1,716 | |||||
BA.1.1* | 21K | Southern Africa (NOV 2021) | 3,812 | |||||
BA.2* | 21L | Southern Africa (NOV 2021) | 5,853 | |||||
BA.3* | 21K | Southern Africa (NOV 2021) | 0 | |||||
BA.4* | 22A | Southern Africa (JAN 2022) | 457 | |||||
BA.5* | 22B | Southern Africa (JAN 2022) | 1,888 | |||||
XE* | N/A | UK (FEB 2022) | 0 | |||||
BQ.1** | 22E | Nigeria (JUL 2022) | 11,841 | |||||
BQ.1.1** | 22B | Nigeria (JUL 2022) | 35,142 | |||||
XBB** | 22F | Multiple Countries (SEP 2022) | 1,120 |
*Variants of concern being monitored by US CDC and WHO.
**Variants not included in CDC or WHO variant of concern list